Doctors use the term “clinical depression” to identify people who need formal, particular treatment for depression. Physicians and counselors use the term “major depression.” People who have major depression have been experiencing a major change in their mood for at least two weeks. The changes can include an abnormally low mood, loss of interest or pleasure, or a very irritable mood. These changes occur most of the day, nearly every day for at least two weeks. The changes are severe enough to affect how you live and work.